Name
EphB2 R Antibody
Catalog number
bs-0247R
Size
0.1ml
Price
263 EUR
Modification(s)
None
Gene ID number
2048
Swiss Prot
P29323
Target Antigen
EphB2 R
French translation
anticorps
Also known as
EphB2 R PAb
Concentration
1ug per 1ul
Conjugation
Unconjugated
Immunogen range
100-150/1055
Subcellular location
Extracellular
Cross reactivity
Human, Mouse, Rat
Category
Primary Antibodies
Modification site(s)
Unmodified antibody
Clonality
Polyclonal antibody
Clone number
Polyclonal antibody
Tested Applications
WB, IHC-P, IF(IHC-P)
Long name
EphB2 R Primary Polyclonal Antibody
Purification method
This antibody was purified via Protein A.
Specificity
This is a highly specific antibody against EphB2 R.
Recommended dilutions
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Cross reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EphB2 R
Storage conditions
Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Properties
If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Synonym names
DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; Ephrin type-B receptor 2; Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH tyrosine kinase 3; EPH-like kinase 5; Renal carcinoma antigen NY-REN-47; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3; EPHB2; EPTH3
Background of the target antigen
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.