Name
EphB2 R Antibody, ALEXA FLUOR 488
Catalog number
bs-0247R-A488
Size
100ul
Price
380 EUR
Gene ID Number
2048
Modification Site
None
Swiss Prot
P29323
Target Antigen
EphB2 R
French translation
anticorps
Tested applications
IF(IHC-P)
Clonality
Polyclonal
Modification
Unmodified
Excitation emission
499nm/519nm
Concentration
1ug per 1ul
Conjugation
Alexa Fluor
Immunogen range
100-150/1055
Subcellular location
Extracellular
Crossreactivity
Human, Mouse, Rat
Conjugated with
ALEXA FLUOR® 488
Clone
Polyclonal antibody
Recommended dilutions
IF(IHC-P)(1:50-200)
Purification
Purified by Protein A.
Category
Conjugated Primary Antibodies
Host Organism
Rabbit (Oryctolagus cuniculus)
Also known as
Anti-EphB2 R PAb ALEXA FLUOR 488
Specificity
This is a highly specific antibody against EphB2 R.
Long name
EphB2 R Polyclonal Antibody, ALEXA FLUOR 488 Conjugated
Cross-reactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Source
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human EphB2 R
Storage conditions
Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Synonyms
DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; Ephrin type-B receptor 2; Developmentally-regulated Eph-related tyrosine kinase; ELK-related tyrosine kinase; EPH tyrosine kinase 3; EPH-like kinase 5; Renal carcinoma antigen NY-REN-47; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase receptor EPH-3; EPHB2; EPTH3
Properties
For facs or microscopy Alexa 1 conjugate.Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), yet the Anti-EphB2 R has a very high photo stability. As a result of this photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry. It is distinguished in the FL1 of a FACS-Calibur or FACScan. Also Alexa Fluor 488 is pH stable.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Background of the antigen
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.