AZD6244, ERK kinase inhibitor

AZD6244, ERK kinase inhibitor

Name

AZD6244, ERK kinase inhibitor

Catalog number

SIH-495-25MG

Size

25 mg

Price

601 EUR

Total weight (kg)

0.25

Net weight (g)

0.025

Purity pourcentage

≥98%

Country of production

Canada

Storage recommendations

-20ºC

PubChem number

10127622

Stock availabilitIn Stock

In Stock

Product type

Inhibitor

Origin

Synthetic

Release date

1-Oct-2014

Molecular weight

457,7 g/mol

CAS number

606143-52-6

Tested applications

To be tested

Tested reactivity

To be tested

Warning information

Non-hazardous

Chemical formula

C17H15BrClFN4O3

Product category

Small Molecules

Shipping recommendations

Shipped Ambient

PubMed number

Refer to PubMed

Description

ERK kinase inhibitor

Physical appearance

White to off-white solid

Soluble in

Soluble in DMSO (92 mg/ml at 25 °C), water (

Bibliography

1. Haasbach E., Hartmayer C., & Planz O. (2013) Antiviral Research. 98(2): 319–324.

Primary research fields

Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors

Scientific context

AZD6244 is a MEK-1 inhibitor. Specifically, AZD6244 inactivates the phosphorylation of ERK1/2.

Other name

Selumetinib, AZD6244, 6-(4-bromo-2-chloroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide

Representative figure legend

Chemical structure of AZD6244 (SIH-495), a ERK kinase inhibitor. CAS #: 606143-52-6. Molecular Formula: C17H15BrClFN4O3. Molecular Weight: 457.7 g/mol. Chemical structure of AZD6244, a ERK kinase inhibitor (SIH-495). CAS # 606143-52-6. Molecular Formula: C17H15BrClFN4O3.

Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

Safety information

Classification: Serious Eye Damage/Eye Irritation, Category 1 Skin Sensitization, Category 1 Toxic To Reproduction, Category 2 Target Organ Systemic Toxicity (repeated exposure), Category 2 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H318: Causes serious eye damage. H317: May cause an allergic skin reaction. H361: Suspected of damaging fertility or the unborn child. H373: May cause damage to {Liver, gastrointestinal tract and other major organs} through prolonged or repeated exposure. Precautionary statements: P280: Wear {protective gloves/protective clothing/eye protection/face protection}. P261: Avoid breathing {dust/fume/gas/mist/vapours/spray}. P272: Contaminated work clothing should not be allowed out of the workplace. P362+364: Take off contaminated clothing and wash it before reuse. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe {dust/fume/gas/mist/vapours/spray}. P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310: Immediately call a {POISON CENTER/doctor/...}. P302+352: IF ON SKIN: Wash with plenty of soap and water. P333+313: If skin irritation or rash occurs, seek medical advice/attention. P308+313: IF exposed or concerned: Get medical attentiodvice. P314: Get medical attentiodvice if you feel unwell.